Table of Contents

• Renal Cell Carcinoma with Sarcomatoid and Rhabdoid Dedifferentiation: Clinico Pathological Significance- Review

  Sunil V. Jagtap, Shubham S. Jagtap ... Devika Borade

  Sarcomatoid and/or rhabdoid dedifferentiation are rare histopathological findings which may be heterogeneous in renal cell carcinoma. Sarcomatoid renal cell carcinoma shows marked cytologic atypia and containing enlarged pleomorphic and malignant spindle cells reminiscent of sarcoma. It is highly aggressive with a high metastatic potential and extremely poor prognosis. ...

  REVIEW | Published: 27 Aug 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 3

  Pages: 90-96   PDF(1900KB)   Views：4853Downloads：49

• Treatment Strategies for BCG Unresponsive Non-muscle Invasive Bladder Cancer

  Anusha Gupta, Shiv Verma, Sanjay Gupta

  Bacillus Calmette-Guérin (BCG) is the standard treatment for patients with non-muscle invasive bladder cancer (NMIBC). Although this therapy has been effective, BCG resistance poses a significant challenge, highlighting the need for alternative treatment options. Possible alternative treatments include intravesical chemotherapy, immunotherapy, antibody-drug conjugates, device-assisted therapies, g...

  REVIEW | Published: 29 Aug 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 3

  Pages: 97-109   PDF(957KB)   Views：2761Downloads：55

• Research Progress of Neoadjuvant Chemotherapy in Advanced Bladder Cancer

  Haijun Hu, Xianghui Wu

  Systemic treatment, commonly referred to as chemotherapy, is a fundamental approach for treating muscle-invasive bladder cancer (MIBC) and metastatic bladder cancer. Neoadjuvant chemotherapy has recently become a standard treatment for MIBC, significantly reducing tumor recurrence rates and improving patient outcomes. Patients may receive adjuvant chemotherapy involving various drug combinations t...

  REVIEW | Published: 09 Sep 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 3

  Pages: 110-117   PDF(718KB)   Views：1539Downloads：16

• Molecular and Clinicopathological Correlates of Wild-Type KRAS Expression in Prostate Cancer

  Henry O. Ebili, Sebastian A. Omenai ... Ngozi Chidozie

  The clinicopathological significance of KRAS alterations in clinical prostate cancer (PCa) has yet to be comprehensively studied, and the classic KRAS somatic mutations are rare in PCa. The clinico-genomic data of two PCa cohorts were retrieved from the cancer genome databases. KRAS expression-based gene enrichment for cell proliferation, apoptosis, and epithelial-mesenchymal transition /invasion ...

  RESEARCH | Published: 31 Jul 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 3

  Pages: 118-131   PDF(2470KB)   Views：1739Downloads：22

• Comparative Analysis of PSA Nadir and Time to PSA Nadir on Clinical Outcomes in Patients with De Novo Spine Metastasis of Prostate Cancer Undergoing Androgen Deprivation Treatment (ADT) Only vs. ADT Intensification

  TAGANG Titus NGWA-EBOGO, Landry Oriol MBOUCHE ... Fru Forbuzshi ANGWAFO III

  Metastatic prostate cancer, particularly with bone involvement, is a severe form of the disease associated with poor prognosis. Androgen deprivation therapy (ADT) has been the standard treatment, but recent strategies suggest that ADT intensification may improve outcomes. This study evaluates the impact of ADT intensification on prostate-specific antigen (PSA) Nadir, time to PSA Nadir, and clinica...

  RESEARCH | Published: 16 Aug 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 3

  Pages: 132-142   PDF(1056KB)   Views：1673Downloads：20

• Research Progress on the Association between Obesity and Prostate Cancer

  Hang Xu, Yingshuang Tang ... Along Kang

  The complex association between obesity and prostate cancer necessitates exploring how obesity impacts the incidence, progression, treatment response, and prognosis of prostate cancer. An analysis was conducted to determine the potential adverse effects of obesity on prostate cancer treatment, including changes in drug metabolism and surgical complications. It also discusses how obesity increases ...

  REVIEW | Published: 18 Jul 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 2

  Pages: 48-54   PDF(686KB)   Views：1740Downloads：21

• Clinical Features and Significance of Malignant Priapism

  Dilibe C. Ekowa, Austin J. Marrah ... Yujiang Fang

  Priapism is a disorder defined as a persistent erection maintained without an appropriate sexual stimulus lasting for longer than 4 hours. Priapism is generally classified into two categories, ischemic and non-ischemic. Ischemic priapism is considered a true urological emergency as prolongation of this subtype is often associated with loss of sinusoidal endothelial function, corporal fibrosis, and...

  REVIEW | Published: 18 Jul 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 2

  Pages: 55-60   PDF(1056KB)   Views：1382Downloads：13

• Exploration of Apoptosis in Histopathologies of Balkan Endemic Nephropathies with Both Urothelial Tumour and Atrophied Kidney

  Peter Mantle, Rohit Upadhyay ... Vecihi Batuman

  There seems yet no satisfactory explanation for the mysterious endemic renal disease, known as Balkan endemic nephropathy (BEN), seen across rural parts of several Balkan countries in the last century although some have claimed aristolochic acid as the etiologic agent. Nearly half of the BEN patients develop urothelial cancers and unilateral nephrectomy may be temporary life-extending measure for ...

  RESEARCH | Published: 04 Jul 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 2

  Pages: 61-69   PDF(1060KB)   Views：1378Downloads：19

• Unveiling the Rarity: A Case Report on Gigantic Primary Scrotal Lipoma

  Sumanta Das, Adil Aziz Khan

  Primary scrotal lipoma is an exceptionally rare finding, typically detected incidentally but posing diagnostic dilemmas when presenting as a substantial mass. Often mistaken initially for inguinal-scrotal hernias or testicular malignancies due to clinical similarities, accurate differentiation is essential for appropriate management. Here, we present a case of a middle-aged male with a massive scr...

  CASE REPORT | Published: 01 Jul 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 2

  Pages: 70-74   PDF(1056KB)   Views：1246Downloads：12

• Incidental Detection of Papillary Renal Cell Carcinoma in Nephrectomy Specimen for Chronic Pyelonephritis

  Sana Ahuja, Adil Aziz Khan, Sufian Zaheer

  Papillary renal cell carcinoma (PRCC), though often asymptomatic in its early stages, presents unique diagnostic challenges. This case report describes the serendipitous discovery of a 1cm PRCC nodule initially missed on radiological investigations. Through meticulous pathological evaluation, PRCC was identified, underscoring the crucial interplay between urological and pathological perspectives. ...

  CASE REPORT | Published: 08 Jun 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 2

  Pages: 75-78   PDF(1730KB)   Views：1219Downloads：18

• Small Cell Neuroendocrine Carcinoma of the Urinary Bladder: A Rare Entity

  Shailaja Shukla, Neha Suman, Srijan Srivastav

  Primary neuroendocrine carcinomas of the urinary bladder are rare accounting for 0.5 to 1 % of all urinary tumours that lacks definitive predisposing factors. However, associations have been noted with old age, history of smoking, long standing cystitis and bladder calculus. These tumours exhibit an aggressive clinical course, often diagnosed at advanced stages due to their close resemblance to ot...

  CASE REPORT | Published: 01 Jun 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 2

  Pages: 79-82   PDF(1500KB)   Views：1362Downloads：24

• Research Progress of New Urine Markers in the Diagnosis of Bladder Cancer

  Rose Lamichhane

  Bladder cancer is the tenth most commonly diagnosed cancer worldwide and poses a great threat to human health. It has a high recurrence rate and requires long-term close monitoring and follow-up after surgery. At present, the most reliable method for the clinical diagnosis of bladder cancer is still cystoscopy and urine exfoliative cytology. However, cystoscopy is an invasive examination, which is...

  REVIEW | Published: 06 Feb 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 1

  Pages: 1-9   PDF(729KB)   Views：3269Downloads：41

• Regulatory Role of Autophagy and Glucose Metabolic Reprogramming in the Malignant Progression of Bladder Cancer: A Review

  Wei Sun, Junxiong Peng ... Mengjuan Yuan

  Bladder cancer is a common malignant tumor of urinary system. Due to the rise of China's aging population, there is an increased pressure on the diagnosis and treatment of bladder cancer continues to increase. Unfortunately, the mechanism(s) of malignant progression of bladder cancer is still unclear, and the current treatment modality for patients with advanced bladder cancer are very limited and...

  REVIEW | Published: 15 Feb 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 1

  Pages: 10-17   PDF(729KB)   Views：1965Downloads：29

• Research Progression in the Mechanism of Bone Metastasis and Bone-Targeted Drugs in Prostate Cancer

  Sajjad Ahmad

  Prostate cancer is a particularly slow growing cancer, the early stage of the disease is not easy to detect, the some major clinical manifestations include low back pain, urgent and frequent urination, urinary pain, and other urethral symptoms. These symptoms are often experienced after surgical resection or drug castration treatment. Early-stage, prostate cancer is curable, and with disease progr...

  REVIEW | Published: 24 Feb 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 1

  Pages: 18-25   PDF(782KB)   Views：3015Downloads：28

• Research Progress of Metabolic Syndrome and Renal Cancer

  Yiwen Wang, Yajun Shi ... Jiao Cao

  Metabolic syndrome (MS) is a condition of metabolic abnormalities in genetically predisposed individuals that are caused by lifestyle habits such as consumption of diet rich in fat and lack of exercise. Few major symptoms include abnormal glucose tolerance, hypertension, abnormal lipid metabolism (including high triglycerides in the blood, low high density lipoprotein cholesterol, etc.), obesity...

  REVIEW | Published: 30 Mar 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 1

  Pages: 26-32   PDF(625KB)   Views：2763Downloads：31

• Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways

  Fawad Inayat, Imad Tariq ... Hadiqa Aimen

  Urologic cancers, with bladder cancer as a pivotal subtype, pose substantial challenges to global health, necessitating a profound understanding of their molecular underpinnings. This article explores recent genomic research, with a focus on transitional cell carcinoma, the primary histological form of transitional cell carcinoma, aiming to elucidate the intricate molecular processes that underlie...

  REVIEW | Published: 20 May 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 1

  Pages: 33-42   PDF(1050KB)   Views：1573Downloads：32

• Exploring Scrotal Leiomyomas, Unraveling the Mysteries of a Rare Tumor: A Case Report

  Sana Ahuja, Pooja Verma ... Sufian Zaheer

  Leiomyomas, originating from smooth muscle cells, are common in the uterus but rare in the scrotum, presenting a clinical challenge. Scrotal leiomyomas, first described in the 19th century, are characterized by benign pathology from the subcutaneous dartos muscle. We present two cases of middle-aged males with scrotal leiomyomas, detailing clinical presentations, histopathological findings, and im...

  CASE REPORT | Published: 30 Jan 2024

  Annals of Urologic Oncology, Volume 7 (2024), Issue 1

  Pages: 43-47   PDF(555KB)   Views：1572Downloads：26

• Diagnosis and Treatment of Adrenal Metastasis in Modern Era

  Sarah E. Matusofsky, Paris M. Fang ... Mark R. Wakefield

  The adrenal glands are a common site of metastases in many advanced stages of cancers such as lung cancer and breast cancer. Given the frequent asymptomatic nature of these adrenal metastatic tumors, patients seldom get screened for adrenal metastases unless otherwise medically indicated for. Therefore, it is essential that screening methods should be as accurate and precise as possible. In this r...

  REVIEW | Published: 11 Nov 2023

  Annals of Urologic Oncology, Volume 6 (2023), Issue 4

  Pages: 127-131   PDF(690KB)   Views：2289Downloads：17

• Research Progress on the Mechanism of Androgen Receptor Signaling Pathway in Castration-Resistant Prostate Cancer

  Na Cui, Mingjie Li

  Prostate cancer (Pca) remains the most common malignancy worldwide in men, and the second leading cause of mortality only to lung cancer. Besides surgery, androgen deprivation therapy (ADT) is a major treatment for Pca. However, ADT leads to the inevitable progression of castration-resistant Pca (CRPC). The transition from hormone-dependent Pca (ADPC) to CRPC has been shown to involve reactivatio...

  REVIEW | Published: 11 Nov 2023

  Annals of Urologic Oncology, Volume 6 (2023), Issue 4

  Pages: 132-138   PDF(581KB)   Views：1831Downloads：17

• Lipid Metabolism Pathway and Renal Tumor Therapy

  Wenjun Wang, Chunyan Xin

  Renal tumor remains as one of the common malignancy of the urinary system whose incidence and mortality is increasing over the years. Although the emergence of targeted drugs has greatly improved the prognosis of patients with advanced kidney cancer, the occurrence of drug resistance still brings huge treatment pressure to patients. Renal clear cell carcinoma (RCC), the most common pathological ty...

  REVIEW | Published: 31 Dec 2023

  Annals of Urologic Oncology, Volume 6 (2023), Issue 4

  Pages: 139-144   PDF(480KB)   Views：2102Downloads：26