Table of Contents

• Metabolic Supremacy Fuels Tumor Aggressiveness in Renal Cancer

  Reham Gholam, Muhammad Khalilzad

  Renal cell carcinoma, with clear cell renal carcinoma (ccRCC) being the dominant form, is recognized as a malignancy driven by abnormal metabolic processes, with extensive alterations in glucose, lipid, and amino acid pathways. The loss of the Von Hippel-Lindau (VHL) gene in nearly 90% of ccRCC instances results in the accumulation of hypoxia-inducible factors (HIFs), producing a pseudo-hypoxic en...

  REVIEW | Published: 02 Mar 2025

  Annals of Urologic Oncology, Articles, Online First

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• Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer

  Beatriz Ramos, Dakota Rogers

  Bladder cancer is among most common malignancies worldwide, with significant morbidity and mortality. Conventional treatment strategies for bladder cancer include transurethral resection, radical cystectomy and chemotherapy. However, the complex immune landscape of bladder cancer involves innate and adaptive immune components that either promote or suppress tumor progression. Upregulation of check...

  REVIEW | Published: 05 Feb 2025

  Annals of Urologic Oncology, Articles, Online First

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• Advances in Illuminating Prostate Cancer with Emerging Phototherapies

  Ali Usman

  Prostate cancer is a worldwide health concern in men, with substantially high incidence rate and advanced metastatic disease-related mortality rates. Despite advancements in diagnostics and treatment options, conventional therapies for prostate cancer, including surgery, radiotherapy, chemotherapy and androgen deprivation therapy, face limitations such as treatment resistance, limited precision an...

  REVIEW | Published: 31 Jan 2025

  Annals of Urologic Oncology, Articles, Online First

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• A Potential Role of MicroRNA in the Renal Cancer and Its Tumor Microenvironment

  Daniel Chikere Ali, Siva Bharath Merugu

  Renal cell carcinoma (RCC) accounts for approximately 2.2% of all diagnosed cancers and 1.8% of cancer-related deaths. Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of RCC, accounting for approximately 70–80% of all cases. Despite significant advancements in therapeutic strategies over recent decades, treatment outcomes for ccRCC patients remain suboptimal. Prognosis for in...

  REVIEW | Published: 29 Jan 2025

  Annals of Urologic Oncology, Articles, Online First

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• Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer

  Haq Dad, Asger Hansen

  Prostate cancer (Pca) is a significant malignancy affecting men's health, with its incidence steadily increasing worldwide in recent years. Among its various subtypes, castration-resistant prostate cancer (CRPC) holds particular importance due to its pivotal role in the progression and management of Pca. The treatment options for Pca range from surgery to medication. However, the mechanisms underl...

  REVIEW | Published: 27 Dec 2024

  Annals of Urologic Oncology, Articles, Online First

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