Table of Contents

• Epigenetic Alterations and Chromatin Landscape Remodeling in Urothelial Bladder Cancer: Molecular Drivers, Biomarker Potential, and Emerging Therapeutic Strategies

  Amr Abd-Elraheem Abdo, Ahmed Mohamed Kamel

  Urothelial carcinoma of the bladder (UBC) is a heterogeneous disease from the clinicopathologic and molecular standpoint and presents clinical management problems for its range in progression, frequent recurrence and complicated genetic/epigenetic architecture. Not only traditional genetic changes, but also epigenetic dysregulation (e.g., alterations of chromatin remodeling, histone modification a...

  REVIEW | Published: 10 Dec 2025

  Annals of Urologic Oncology, Articles, Online First

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• Testicular Carcinoma: Molecular Pathogenesis, Diagnostic Advances, and Evolving Therapeutic Strategies

  Aadhira Aiyar, Alina Roos

  Testicular carcinoma is the most common solid tumor in young male patients. Despite a high rate of survival, current treatments come with significant long-term toxicities, highlighting the need for more precise diagnostics and therapies. The current review focuses on the molecular pathogenesis, diagnostic development and evolving treatments of testicular germ cell tumors (TGCTs). TGCTs arise from ...

  REVIEW | Published: 30 Nov 2025

  Annals of Urologic Oncology, Articles, Online First

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• Eosinophilic Solid and Cystic Renal Cell Carcinoma Presenting as Bone Metastasis: A Case Report and Literature Review

  Madhu Mitha, Sindhu Ramamurthy ... Pushpa Bhari Thippeswamy

  Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is a recently characterized renal neoplasm, typically indolent, with rare instances of metastasis. We report an 85-year-old male patient presenting with left knee pain. Magnetic resonance imaging (MRI) revealed an osteolytic lesion in the left proximal tibia. Subsequent imaging identified a primary renal mass with renal vein thrombosis. ...

  CASE REPORT | Published: 28 Nov 2025

  Annals of Urologic Oncology, Articles, Online First

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• Precision Medicine in Prostate Cancer: The Role of Molecular Diagnostics and Targeted Therapies

  Amira Guedouar, Enas Roumieh

  Prostate cancer is a major health problem in the world, and it has been complicated by the fact that the illness is quite heterogeneous. In the past, the use of PSA testing and histopathological grading has been constrained by failure to reliably distinguish between indolent and aggressive cancer. In this review, the concept of a fundamental change in the field of prostate cancer treatment, facili...

  REVIEW | Published: 21 Nov 2025

  Annals of Urologic Oncology, Articles, Online First

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• Exploiting Metabolic Reprogramming and Its Therapeutic Vulnerabilities in Prostate Cancer

  Ukasha Ahmed

  Prostate cancer is a metabolically distinct malignancy as it exhibits strong flexibility in how it uses energy and perform physiological processes. In contrast to many solid tumors which mostly depend on aerobic glycolysis, the primary prostate cancer cells still depend mainly on oxidative phosphorylation and tricarboxylic acid (TCA) cycle for energy supply. This unique metabolic pattern is mainly...

  REVIEW | Published: 18 Nov 2025

  Annals of Urologic Oncology, Articles, Online First

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• Evolving Therapeutic Paradigms in Bladder Cancer: The Impact of Immunotherapy and Antibody-Drug Conjugates

  Shahd Mustafa Ibrahim, Ahmed Attia Ahmed Abdelmoaty, Ahmed Helmy Abdelhaseb

  Bladder cancer is a significant global health challenge. Despite advances in surgery and platinum-based chemotherapy over the decades, limited improvements in clinical outcomes have been observed. However, recent years have witnessed the development of immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs) that has transformed the therapeutic landscape of bladder cancer across dif...

  REVIEW | Published: 24 Oct 2025

  Annals of Urologic Oncology, Articles, Online First

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• Incidentally Discovered Primary Renal Leiomyosarcoma in a Middle Aged Female Presenting with Symptoms of Incomplete Abortion: A Rare Case Report

  Rashi Maheshwari, Shikhar Chohan ... Sufian Zaheer

  Background Primary renal leiomyosarcoma (LMS) is an exceptionally rare malignant mesenchymal tumor, constituting <1.5% of all primary renal malignancies. Diagnosis is difficult because clinical and radiologic features overlap with other renal neoplasms. Case Presentation We describe a 37-year-old woman, notably younger than the typical age reported for renal LMS, who presented with abnormal uteri...

  CASE REPORT | Published: 23 Sep 2025

  Annals of Urologic Oncology, Articles, Online First

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• A Diagnostic Twist: Primary Bladder Adenocarcinoma Masquerading as an Ovarian Torsion: A Case Report on Unusual Cystic Presentation

  Sonali Kar, Neeta Verma, Suren Kumar Das

  Primary bladder adenocarcinoma (PBA) is a rare malignancy comprising of only 0.5–2% of all bladder cancers and typically presents with nonspecific urinary symptoms. Cystic presentation is extremely uncommon and can mimic other pelvic pathologies. We report a very rare case of PBA in a 40-year-old female initially diagnosed as ovarian torsion based on clinical features and ultrasound findings. Intr...

  CASE REPORT | Published: 15 Sep 2025

  Annals of Urologic Oncology, Articles, Online First

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