Table of Contents

• Testicular Carcinoma: Molecular Pathogenesis, Diagnostic Advances, and Evolving Therapeutic Strategies

  Aadhira Aiyar, Alina Roos

  Testicular carcinoma is the most common solid tumor in young male patients. Despite a high rate of survival, current treatments come with significant long-term toxicities, highlighting the need for more precise diagnostics and therapies. The current review focuses on the molecular pathogenesis, diagnostic development and evolving treatments of testicular germ cell tumors (TGCTs). TGCTs arise from ...

  REVIEW | Published: 30 Nov 2025

  Annals of Urologic Oncology, Volume 8 (2025), Issue 4

  Pages: 167-176   PDF(1340KB)   Views：305Downloads：3

• Evolving Precision Therapy Paradigm against Adrenocortical Carcinoma

  Declan Moore, Wayway Li

  Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine cancer type, posing significant clinical challenges due to its diverse molecular features and poor treatment outcomes. At the molecular level, abnormalities in pathways, such as IGF2 signaling, Wnt/β-catenin activation, cell-cycle regulation, DNA damage repair, chromatin remodeling, and steroidogenesis have been implicated in...

  REVIEW | Published: 20 Dec 2025

  Annals of Urologic Oncology, Volume 8 (2025), Issue 4

  Pages: 177-187   PDF(2720KB)   Views：116Downloads：1

• Non-Histone Chromatin Protein Dysregulation: The Oncogenic Role of HMGB1 and Its Redox States in ccRCC Inflammation and Genome Instability

  Betty Alex

  High Mobility Group Box 1 (HMGB1) is non-histone chromatin protein that plays important roles in maintaining nuclear architecture, transcriptional modulation, DNA replication, chromatin restructuring and DNA damage repair. In addition to its classical nuclear roles, HMGB1 predominantly functions as an extracellular alarmin and damage-associated molecular pattern (DAMP) signal that stimulates vario...

  REVIEW | Published: 22 Dec 2025

  Annals of Urologic Oncology, Volume 8 (2025), Issue 4

  Pages: 188-199   PDF(1270KB)   Views：97Downloads：1

• Prostate-Specific Membrane Antigen (PSMA) PET-CT: Revolutionizing Staging, Restaging, and Treatment Response Assessment

  Theo Smith, Mia Harper

  Prostate-specific membrane antigen (PSMA) positron emission tomography–computed tomography (PET-CT), has become the benchmark imaging tool in the management of prostate cancer, due to its unparalleled precision in staging, restaging and assessing of treatment response. Traditional imaging modalities, such as computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy, suffer f...

  REVIEW | Published: 28 Dec 2025

  Annals of Urologic Oncology, Volume 8 (2025), Issue 4

  Pages: 200-210   PDF(1160KB)   Views：62Downloads：2

• Epigenetic Alterations and Chromatin Landscape Remodeling in Urothelial Bladder Cancer: Molecular Drivers, Biomarker Potential, and Emerging Therapeutic Strategies

  Amr Abd-Elraheem Abdo, Ahmed Mohamed Kamel

  Urothelial carcinoma of the bladder (UBC) is a heterogeneous disease from the clinicopathologic and molecular standpoint and presents clinical management problems for its range in progression, frequent recurrence and complicated genetic/epigenetic architecture. Not only traditional genetic changes, but also epigenetic dysregulation (e.g., alterations of chromatin remodeling, histone modification a...

  REVIEW | Published: 10 Dec 2025

  Annals of Urologic Oncology, Volume 8 (2025), Issue 4

  Pages: 211-221   PDF(3150KB)   Views：223Downloads：1