Table of Contents

• Targeting CTLA-4 in Cancer: Biological Insights with a Focus on Renal Cell Carcinoma

  Juan Wu, Ya-fei Ren ... Dong-sheng Li

  Renal cell carcinoma (RCC) is a complex group of malignant tumors characterized by immunosuppression and high invasiveness. In the majority of patients with advanced renal cell carcinoma, treatment fails to achieve a complete cure post-treatment. Efforts are needed to develop new therapeutics to improve the outcome of renal cell carcinoma. The "immune checkpoint" of T cells has attracted much atte...

  REVIEW | Published: 21 Dec 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 2

  Pages: 68-74   PDF(1000KB)   Views：2018Downloads：13

• Research Progress on Ferroptosis as a Therapeutic Strategy in Renal Cell Carcinoma

  Minna Liu, Min Bai ... Peng Zhang

  Renal cell carcinoma (RCC) is a common type of kidney cancer in adults and constitutes approximately 90% of all renal malignancies. Although advancements have been made in the treatment of RCC, the 5 -year survival rate is still low, and new treatment modalities are still required. Ferroptosis is an iron-dependent programmed cell death caused by the accumulation of lipid peroxide products. Recent ...

  REVIEW | Published: 16 Dec 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 2

  Pages: 75-80   PDF(886KB)   Views：1655Downloads：7

• Recent Advances in Advance Prostate Cancer

  Nishant Lohia

  Prostate cancer being the second most frequent and fifth leading cause of mortality has led to conduct of many new clinical trials and development of newer therapeutic agents. In the last decade with better understanding of biology of disease there is dramatic improvement and sea change in survival outcomes in advanced prostate cancer with advent of chemotherapy, targeted therapy immunotherapy bes...

  REVIEW | Published: 30 Dec 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 2

  Pages: 81-88   PDF(525KB)   Views：1407Downloads：13

• Long Non-coding RNA INE1 Induced Autophagy Promotes Sensitivity of Prostate Cancer Cells to Cisplatin

  Hezhen Chu, Kongdong Li ... Jun Ma

  Prostate cancer is most prevalent malignancy of males in the world. In recent years, long non-coding RNAs (lncRNAs) were identified, and their functions are associated with prostate cancer initiation and progression. However, their molecular mechanisms still need to be elucidated before the clinical utility. In the present study, we identified the correlation of lncRNA inactivation escape 1 (INE1)...

  RESEARCH | Published: 29 Nov 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 2

  Pages: 89-100   PDF(2470KB)   Views：1316Downloads：6

• Update on How to Improve the Outcome of Radical Cystectomy: A Systematic Review

  Ahmed M. Moeen, Hassan A Aboul-Ella

  Radical cystectomy (RCX) is the most difficult urologic procedure. It is usually performed in patients with morbidities and associated with a high rate of complications. So, every effort must be done to improve the outcome of this surgery. This systematic review tries to put an up to date analysis of the literature on how to improve the outcome of RCX. Evidence acquisition A systematic literature...

  REVIEW | Published: 19 May 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 1

  Pages: 1-7   PDF(1250KB)   Views：1848Downloads：6

• Is Robotic-assisted Partial Nephrectomy an Efficacious and Safe Procedure for Removal of Stage T1 Renal Tumors?

  Deshraj Choudhary, Shams Tabrej Asgarali Ansari ... Saqib Shahab

  Robotic surgery has now evolved as an emerging tool for better and easy operative techniques. The quest for trifecta comprising warm ischemia time less than 25 minutes, negative surgical margins and no perioperative complications seems to be better accomplished by robotic partial nephrectomy, which is likely to become the new standard for minimally invasive partial nephrectomy. It is a prospective...

  RESEARCH | Published: 13 Apr 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 1

  Pages: 8-19   PDF(1360KB)   Views：2588Downloads：6

• Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

  Amit V Varma, Seema Jindal ... Pooja Kesharwani

  Prostate cancer (PCa) is the second most frequent malignancy (after lung cancer) in men worldwide. In prostate cancer, immunohistochemistry (IHC) has an important role in the diagnostic confirmation. Gleason score, tumour volume, surgical margins and Ki-67 index are the most significant prognostic factors. The value of different biomarkers like p53, Ki-67, PSMA, androgen receptor mutations, IGF, E...

  RESEARCH | Published: 30 Aug 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 1

  Pages: 20-33   PDF(2310KB)   Views：1881Downloads：11

• Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer: A Mono-institutional Series

  Riccardo Vigna-Taglianti, Alberto Boriano ... Elvio Grazioso Russi

  The development of new metabolic diagnostic imaging PET is changing the history of metastatic prostate cancer (pCa), identifying situations of progression with a low disease burden; radiation treatment of metabolically active oligometastatic sites has been shown to be effective to prolong patient survival. In the scenario of oligometastatic disease to pelvic lymph nodes there is no uniform consens...

  RESEARCH | Published: 06 Oct 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 1

  Pages: 34-41   PDF(860KB)   Views：1639Downloads：5

• Long Non-coding RNA FAM66C Promotes Prostate Cancer Metastasis via JNK-Mediated Proteasome and Lysosomal Pathway

  Zhenqian Qin, Kongdong Li ... Xuefeng Yuan

  A lower expression of lncRNA FAM66C was noted in the most prostate cancer patients. Knockdown of FAM66C in human prostate cancer DU145 and PC-3 cells promoted EMT and cell migration, which was suppressed by proteasomal inhibitor MG132 and lysosomal inhibitor CQ. Knockdown of FAM66C induced JNK signaling, cell migration and invasion, and activation of proteasome and lysosome pathways were suppresse...

  RESEARCH | Published: 29 Nov 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 1

  Pages: 42-51   PDF(2010KB)   Views：1472Downloads：7

• Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt

  Sriram Krishnamoorthy, Hariharasudhan Sekar ... J. Sathish Kumar

  Pseudoepitheliomatous hyperplasia (PEH) is a benign condition marked by reactive epithelial proliferation seen in response to various insults like trauma, infection, persistent inflammation and neoplasia. In this report, we discuss a case of a 35-year-old man who presented with a perineal swelling, later turned into a non-healing ulcer, first diagnosed as PEH. Still, after clinical suspicion, a de...

  CASE REPORT | Published: 25 Dec 2022

  Annals of Urologic Oncology, Volume 5 (2022), Issue 1

  Pages: 52-56   PDF(1240KB)   Views：1874Downloads：10

• A Case of Malignant Pheochromocytoma of the Adrenal Gland in a Young Female

  Veda Murthy Reddy Pogula, Ershad Hussain Galeti ... Ayesha Galeti

  Pheochromocytoma is a tumour of the adrenal medulla, derived from catecholamine producing chromaffin cells. Malignant pheochromocytomas constitute 10–25% of all cases. These are difficult to diagnose microscopically. Therefore, malignant pheochromocytomas are diagnosed by the presence of local invasion or metastatic disease. Case presentation We present a case of malignant Pheochromocytoma in a 20...

  CASE REPORT | Published: 30 Dec 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 2

  Pages: 48-55   PDF(1060KB)   Views：2147Downloads：7

• A Rare Case of Post Radiation Urinary Bladder Necrosis in a Patient with Carcinoma Cervix

  Karthikesh Omkaram, Mallikarjuna Reddy Nalabolu ... Ayesha Galeti

  In contrast to proctitis, vaginitis and acute radiation cystitis, late urological complications after pelvic irradiation are rarer, more serious and irreversible. The main disadvantage of radiotherapy is the fact that it affects both cancer and healthy cells located in the tumour area. As a consequence, different complications develop. A large proportion of cancers treated with radiotherapy are lo...

  CASE REPORT | Published: 31 Dec 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 2

  Pages: 56-61   PDF(2396KB)   Views：2312Downloads：7

• Giant Adrenal Myelolipoma Treated by Laparoscopic Excision: A Case Report and Review of Literature

  Veda Murthy Reddy Pogula, Ershad Hussain Galeti ... Ayesha Galeti

  Adrenal myelolipoma is inevitably a benign neoplasm of the adrenal gland. It is the second most common primary adrenal incidentaloma after adrenocortical adenomas. Adrenal myelolipoma is a rare, benign and non-functional neoplasm, composed of mature adipose and hematopoietic tissue which closely resembles bone marrow. Most of these lesions are small, unilateral and asymptomatic, discovered inciden...

  CASE REPORT | Published: 31 Dec 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 2

  Pages: 62-68   PDF(1550KB)   Views：2073Downloads：10

• Non-Muscle Invasive Micropapillary Urothelial Carcinoma of the Bladder: Variable Use of Initial Cystectomy versus Intravesical Bacillus Calmette-Guérin

  Karishma Gupta, Danly Omil-Lima ... Kyle Scarberry

  Micropapillary urothelial carcinoma (MPUC) is a rare and aggressive histologic variant of bladder cancer. Treatment guidelines recommend forgoing Bacillus Calmette-Guérin (BCG) therapy in favor of early radical cystectomy for non-muscle invasive (NMI)-MPUC due to high rates of disease progression. We aimed to evaluate its management in patients with immediate cystectomy and BCG across various cen...

  RESEARCH | Published: 31 Dec 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 2

  Pages: 69-79   PDF(457KB)   Views：1786Downloads：9

• Oncolytic and Immunotherapeutic CG0070 Adenovirus for High-Risk Bacillus Calmette-Guerin Unresponsive Bladder Cancer

  Evan Austin, Debra Mobley ... Donald Lamm

  To evaluate the response of patients with high-risk bacillus Calmette-Guerin (BCG)–unresponsive non-muscle invasive bladder cancer (NMIBC) who we treated with intravesical CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor (GM-CSF) containing an RB promoter. Methods 15 patients with residual high grade BCG-unresponsive CIS +/- Ta/T1/T2 bladder cancer received one...

  RESEARCH | Published: 31 Dec 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 2

  Pages: 80-86   PDF(633KB)   Views：1799Downloads：15

• Isolated Tuberculous Epididymal Mass Mimicking Testicular Malignancy: An Interesting Case Report and Lessons Learnt

  Tejaswini Manne, Solomon Nazareth ... Natarajan Kumaresan

  Tuberculous epididymal mass is a condition that presents as a painless scrotal swelling. It resembles a testicular mass and is more often diagnosed after orchidectomy. About 22% of all genitourinary tuberculosis show epididymal involvement and 22% of epididymal tuberculosis are bilateral. This report reiterates the need for an increased awareness amongst the treating urologists that would enable a...

  CASE REPORT | Published: 22 May 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 1

  Pages: 1-4   PDF(1090KB)   Views：3138Downloads：8

• Isolated Large Renal Hydatid Cyst Treated by Laparoscopic Nephrectomy

  Veda Murthy Reddy Pogula, Ershad Hussain Galeti ... Ayesha Galeti

  Hydatid disease is caused by Echinococcus granulosus, which causes rare isolated presentation in the kidneys, and is estimated to be about 2-4% of all cases. We herein present a case of a 45-year-old symptomatic male patient with a large primary hydatid cyst in the left kidney that was treated successfully by laparoscopic left nephrectomy....

  CASE REPORT | Published: 20 Aug 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 1

  Pages: 5-9   PDF(1020KB)   Views：1650Downloads：6

• Squamous Cell Carcinoma of the Urinary Bladder: Clinicopathological and Molecular Update -Review

  Sunil Vitthalrao Jagtap, Swati S Jagtap ... Snigdha Vartak

  Urinary bladder cancer is one of the most prevalent cancers worldwide.Squamous Cell Carcinoma (SCC) is an uncommon subtype of urinary bladder carcinoma.It is a malignant epithelial neoplasm arising in the urinary bladder demonstrating a pure squamous cell phenotype. On histopathology it is considered when tumor is showing pure squamous morphology without any component of conventional urothelial ca...

  REVIEW | Published: 15 Jul 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 1

  Pages: 10-17   PDF(2060KB)   Views：9673Downloads：43

• Hereditary Renal Cell Tumors: Clinicopathologic Importance

  Harmanjot Singh, Mukul K. Divatia ... Jae Y. Ro

  Hereditary renal cancer syndromes represent approximately 5% of renal malignancies and have distinctive clinical, histopathologic, and genetic features. Next-generation sequencing and other molecular testing methods have uncovered several hereditary renal cancer syndromes. Several autosomal dominant hereditary renal cell carcinoma (RCC) syndromes, including those related to germline pathogenic var...

  REVIEW | Published: 15 Oct 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 1

  Pages: 18-30   PDF(4520KB)   Views：3067Downloads：7

• Roles of Renin-Angiotensin System in the Regulation of Prostate Cancer Bone Metastasis: A Critical Review

  Manh Tien Tran

  Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from (1) the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption and from (2) the anti-tumor immune respon...

  REVIEW | Published: 15 Oct 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 1

  Pages: 31-41   PDF(723KB)   Views：2517Downloads：5