Table of Contents

• Roles of Renin-Angiotensin System in the Regulation of Prostate Cancer Bone Metastasis: A Critical Review

  Manh Tien Tran

  Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from (1) the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption and from (2) the anti-tumor immune respon...

  REVIEW | Published: 15 Oct 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 1

  Pages: 31-41   PDF(723KB)   Views：2649Downloads：5

• Correlation between Serum PSA, Gleason Score and Histopathological Grading of Adenocarcinoma of Prostate in Patients Undergoing TRUS Guided Prostatic Biopsy in a Tertiary Care Centre of Southern India

  Veda Murthy Reddy Pogula, Karthikesh Omkaram ... Bhargava Reddy Kanchi V

  Prostate cancer is the second most common cancer and the fifth leading cause of cancer deaths worldwide. Serum psa, a glycoprotein and a serine protease, which is increased in all prostatic diseases but markedly elevated levels are indicative of carcinoma prostate. The present study was done to evaluate the histopathologyof carcinoma of prostate in trus guided prostatic biopsy specimens and correl...

  RESEARCH | Published: 20 Dec 2021

  Annals of Urologic Oncology, Volume 4 (2021), Issue 1

  Pages: 42-47   PDF(909KB)   Views：2390Downloads：29

• Open Radical Retropubic Prostatectomy as a Saviour in the Era of Robotics- A Single Surgeon Experience

  Abdul Rouf Khawaja, Malik Abdul Rouf ... Mohd.Saleem Wani

  Outcome of its safety, perioperative outcomes, functional outcomes, oncologic outcomes in open radical retropubic prostatectomy for organ confined prostate cancers in the era of robotic surgery. A prospective study of radical retropubic prostatectomy performed at SKIMS between 2013 and 2020 was conducted. Work up of the patients in the study (n=42) included age, comorbidities, serum prosta...

  RESEARCH | Published: 10 Oct 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 2

  Pages: 54-60   PDF(2060KB)   Views：4952Downloads：7

• Short Term Outcomes in Indian Patients with High Risk Prostate Cancer after Laparoscopic Radical Prostatectomy- Data from a Single Institute

  Prashant Patel, Shrenik J Shah, Arpan Choudhary

  Management of high risk prostate cancer (HRPC) is in evolving stage. Effectiveness of the various treatment strategies is being explored. We examined the short term efficacy of laparoscopic radical prostatectomy (LRP) in treatment of patients with HRPC. Retrospective observational study had 140 HRPC patients of Indian origin, based on D’Amico classification system. Baseline workup was completed. ...

  RESEARCH | Published: 04 Oct 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 2

  Pages: 61-70   PDF(837KB)   Views：2669Downloads：6

• Long Non-coding RNAs in Castration-resistant and Neuroendocrine Prostate Cancer: Potential Role and Therapeutic Impact

  Kumari S. Prajapati, Atul K. Singh ... Sanjay Gupta

  Prostate cancer is the most commonly diagnosed malignancy and leading cause of cancer-related deaths in men worldwide. The disease is heterogeneous in nature exhibiting various clinical subtypes and genetic/transcriptomic features. Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that does not encode any protein and play important role in several biological processes as ...

  REVIEW | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 2

  Pages: 71-81   PDF(1270KB)   Views：2886Downloads：8

• Comparative Study of Histological Changes (Thermal Artefacts) in Resected Specimens of Monopolar and Bipolar Trans-Urethral Resection of Bladder Tumours

  Vasudevan Thirugnanasambandam, Jeyaraman Ramanathan

  The primary aim of the study was to study the histological changes (Thermal artefacts) noted in the resected specimens between the Monopolar and Bipolar Trans-Urethral Resection of Bladder Tumours (TURBT). The study was done between March 2012 and Feb 2013. This was a comparative study between Monopolar and Bipolar resection specimens studied for histological changes (Thermal artefacts). Institu...

  RESEARCH | Published: 04 Nov 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 2

  Pages: 82-88   PDF(939KB)   Views：2763Downloads：9

• Minimal Invasive Treatments for Renal Cell Carcinoma

  Selahattin Çalışkan, Mustafa Sungur

  Renal cell carcinoma (RCC) is the most common malignancy of the kidney that accounts 85% of all renal tumors and 2-3% of all adult malignancies . The etiology of RCC associated with smoking , obesity, anti-hypertensive therapy, coffee and tea, Western diet (high fat and protein and low fruits and vegetables). However, the detection of small renal masses has been increased because of widespread us...

  REVIEW | Published: 05 Oct 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 2

  Pages: 89-96   PDF(1080KB)   Views：2999Downloads：11

• Multilocular Cystic Renal Neoplasm-Low Malignant Potential (MCRN-LMP) - Review

  Sunil Vitthalrao Jagtap

  Multilocular Cystic Renal Neoplasm of Low Malignant Potential (MCRN-LMP), previously known as multilocular cystic renal cell carcinoma as a rare variant of cystic kidney. It is composed of multiple cysts separated by thin septa covered with clear cells with no expansile growth. The termMCRN-LMPshould be used exclusively to identify a cystic kidney lesion with a small clusters of neoplastic clear c...

  REVIEW | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 2

  Pages: 97-102   PDF(874KB)   Views：11731Downloads：17

• Vascular Neoplasms and Related Lesions of Kidney

  Michelle S. Lin, Jae Y. Ro

  Vascular tumors arising in the kidney are distinctly uncommon occurrences and have not been well-characterized in the literature; most cases have been documented in single reports or small case series. These tumors often exhibit nonspecific clinical and radiologic features and may mimic malignant epithelial tumors such as renal cell carcinoma (RCC) on imaging studies, necessitating nephrectomy wit...

  REVIEW | Published: 25 Jun 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 1

  Pages: 1-14   PDF(2840KB)   Views：7151Downloads：39

• Histopathological Review of Renal Pelvic Tumours of Balkan Nephropathy Cases from Southern Serbia

  Diana Herman, Goran Stanojević ... Peter Mantle

  Urothelial tumour frequently associates with atrophied kidney pelvis in Balkan endemic nephropathy but histopathology illustration lacks both definition and immune profile for differential diagnosis from renal cell carcinoma. Histology sections of anonymized archived renal tumours and associated kidney of eight local Balkan nephropathy patients were stained by haematoxylin and eosin, and immune pr...

  RESEARCH | Published: 17 Jul 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 1

  Pages: 15-21   PDF(5240KB)   Views：3231Downloads：4

• Multilocular Cystic Renal Neoplasm of Low Malignant Potential: Mimicker of Cystic Clear Cell Carcinoma – Urologist’s Perspective

  Harish Challa, Hariharasudhan Sekar ... Natarajan Kumaresan

  Multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) is a rare subtype of clear cell renal cell carcinoma (ccRCC) accounting for 2-4% of RCC. It is defined as a neoplasm that is composed entirely of numerous cysts surrounded by fibrous capsule and septa containing clear cells without expansile growth or mural nodules (WHO 2016). The purpose of this manuscript is to highlight tha...

  CASE REPORT | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 1

  Pages: 22-26   PDF(1046KB)   Views：3475Downloads：7

• Effects of P-MAPA as Immunomodulator on Markers for Energy Metabolism in Bladder Cancer

  Wagner J. Fávaro, Petra K. Böckelmann ... N. Durán

  This study characterized and compared cellular energetic metabolism features in the treatment of chemically induced non-muscle invasive bladder cancer (NMIBC) in Fischer 344 rats that were submitted to intravesical immunotherapies with P-MAPA (Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride) and Bacillus Calmette-Guérin (BCG). Our results showed that immunotherapy with...

  RESEARCH | Published: 01 Aug 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 1

  Pages: 27-35   PDF(3250KB)   Views：5212Downloads：5

• Histologic Variants of Acinar Prostate Carcinomas: Clinicopathologic Importance

  Harmanjot Singh, Ziad M. El-Zaatari, Jae Y. Ro

  Acinar carcinoma comprises more than 90% of prostatic adenocarcinomas and is characterized by a small gland proliferation with an infiltrative growth pattern. The numerous, variably-defined histological variants of prostatic adenocarcinoma can prove to be diagnostic challenges and show prognostic differences when compared to the usual acinar carcinoma, thus emphasizing the importance in accurate r...

  REVIEW | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3 (2020), Issue 1

  Pages: 36-46   PDF(4187KB)   Views：4038Downloads：39

• Histopathological Variant Types Diagnosed in Prostate Surgery

  Semih Aktaş, Hikmet Köseoğlu ... Sevim Baykal Koca

  Rare pathological variants may only be diagnosed after the surgical treatments applied. We aimed to determine the rare variant pathologies and their frequencies diagnosed in prostate surgeries performed in routine patient care. We retrospectively analyzed hospital pathology records for all prostate surgeries performed namely TUR-P, open prostatectomy, and radical prostatectomy between October 2014...

  RESEARCH | Published: 31 Dec 2021

  Annals of Urologic Oncology, Volume 3 (2020), Issue 1

  Pages: 47-53   PDF(4790KB)   Views：2210Downloads：6

• Robot-Assisted Radical Cystectomy: State of Art and Future Perspectives

  Riccardo Mastroianni, Giuseppe Simone

  Bladder cancer (BC) remains one of the most common cancer worldwide. Radical cystectomy (RC) and pelvic lymph node dissection (PLND) with urinary diversion (UD) is still considered the gold standard treatment for non-metastatic muscle invasive bladder cancer (MIBC) and for recurrent non-muscle invasive disease. The open approach remains the reference option of treatment for RC, even if robotic sur...

  REVIEW | Published: 26 Dec 2019

  Annals of Urologic Oncology, Volume 2 (2019), Issue 2

  Pages: 50-56   PDF(6080Kb)   Views：2881Downloads：3

• Progress in Research on Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) and Bladder Cancer

  Wei-Ming Fang, Chun Chen

  Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) was first discovered in 1987 and confirmed to be a protein that is mainly expressed on the surface of activated lymphocytes. CTLA-4 is expressed on the surface of T cells and binds to B7 expressed on antigen presenting cells (APCs) to potentially play a role in inhibiting lymphocyte proliferation. Inhibitors of CTLA-4 were developed to promote t...

  REVIEW | Published: 24 Jan 2019

  Annals of Urologic Oncology, Volume 2 (2019), Issue 2

  Pages: 57-63   PDF(781KB)   Views：5002Downloads：7

• Measurement of DNA Damage in Bladder Cancer Patients by Alkaline Comet Assay

  Jahidul Islam, Yearul Kabir

  Bladder cancer is the most common cancer of the urinary tract. This is the first attempt to use alkaline comet assay to evaluate DNA damage in Bangladeshi bladder cancer patients. The results of this study may emphasize to use ACA for routine DNA damage detection, which could be used as a prognostic biomarker of bladder cancer....

  RESEARCH | Published: 29 Dec 2019

  Annals of Urologic Oncology, Volume 2 (2019), Issue 2

  Pages: 64-70   PDF(1020Kb)   Views：3574Downloads：3

• Immunotherapy Landscape in Prostate Cancer: Successes, Failures and Promises

  Sabeeh-ur-Rehman Butt, Muhammad S Khan ... Anna Patrikidou

  As research focus in oncology has recently shifted to immunomodulation, the era of introduction of immunotherapeutic agents in the management of prostate cancer has just begun. With the success of checkpoint blockade drugs in certain advanced tumours, ongoing efforts are aimed at identification and validation of new actionable immune targets to consolidate and expand the initial success in other t...

  REVIEW | Published: 15 Sep 2019

  Annals of Urologic Oncology, Volume 2 (2019), Issue 2

  Pages: 71-88   PDF(1680KB)   Views：4850Downloads：4

• Mutations in Cancer Driver Genes: An Insight into Prostate Cancer Progression

  Sahdeo Prasad, Sanjay K Srivastava

  Prostate cancer is one of the most common uro-oncological disease in men and is globally leading cause of cancer related deaths in males. The somatic mutation has a strong link in the occurrence of cancer. Mutation in the oncogenes and tumor suppressor genes that alter key cellular functions can lead to prostate cancer initiation and progression. Whole genome sequencing has identified numerous gen...

  REVIEW | Published: 22 Sep 2019

  Annals of Urologic Oncology, Volume 2 (2019), Issue 2

  Pages: 89-95    PDF(568KB)   Views：4406Downloads：6

• Noncoding RNAs and Its Implication as Biomarkers in Renal Cell Carcinoma: A Systematic Analysis

  Shiv Verma, Sanjay Gupta

  Renal cell carcinoma (RCC) is one of the most devastating disease with higher mortality rates. It comprises several subtypes exhibiting distinct histological features and clinical staging. Despite recent advancement in understanding the biology of RCC success in treatment rates remains dismal. This may be partly due to lack of specific biomarkers for early detection/prognosis and poor clinical out...

  REVIEW | Published: 05 Apr 2019

  Annals of Urologic Oncology, Volume 2 (2019), Issue 2

  Pages: 96-106   PDF(1210KB)   Views：4189Downloads：5