All Articles

• RESEARCH  |  29 Dec 2019

  Measurement of DNA damage in bladder cancer patients by alkaline comet assay

  JAHIDUL ISLAM, YEARUL KABIR. Background Bladder cancer is the most common cancer of the urinary tract. DNA damage is responsible for genomic instability, which is a hallmark of bladder carcinogenesis. Cigarette smoking induced DNA damage is one of the major risk factors associated with this disease. Methods We used the alkaline comet assay to measure DNA damage in peripheral blood lymphocytes from...

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• REVIEW  |  29 Dec 2019

  Robot-assisted radical cystectomy: state of art and future perspectives

  RICCARDO MASTROIANNI, GIUSPPE SIMONE. Bladder cancer (BC) remains one of the most common cancer worldwide. Radical cystectomy (RC) and pelvic lymph node dissection (PLND) with urinary diversion (UD) is still considered the gold standard treatment for non-metastatic muscle invasive bladder cancer (MIBC) and for recurrent non-muscle invasive disease. The open approach remains the reference option of...

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• RESEARCH   |  04 Nov 2019

  Trends in Primary Kidney Cancer: A South Australian Registry Review

  RICHARD HOFFMAN, ARMAN KAHOKEHR, MICHAEL O'CALLAGHAN, KATINA D'ONISE et al. Background The incidence of primary kidney cancer (PKC) has been increasing over the last three decades. This has been attributed to the liberal use of radiological examinations for unrelated indications. We investigated the incidence and survival trends of PKC in South Australia. Methods Data were provided through the So...

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• REVIEW  |  22 Sep 2019

  Mutations in Cancer Driver Genes: An Insight into Prostate Cancer Progression

  SAHDEO PRASAD, SANJAY K SRIVASTAVA. Prostate cancer is one of the most common uro-oncological disease in men and is globally leading cause of cancer related deaths in males. The somatic mutation has a strong link in the occurrence of cancer. Mutation in the oncogenes and tumor suppressor genes that alter key cellular functions can lead to prostate cancer initiation and progression. Whole genome se...

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• REVIEW  |  15 Sep 2019

  Immunotherapy Landscape in Prostate Cancer: Successes, Failures and Promises

  SABEETH-UR-REHMAN BUTT, MUHAMMAD S KHAN, CARMEN MURIAS, MARIA REYES GONZALEZ-EXPOSITO et al. As research focus in oncology has recently shifted to immunomodulation, the era of introduction of immunotherapeutic agents in the management of prostate cancer has just begun. With the success of checkpoint blockade drugs in certain advanced tumours, ongoing efforts are aimed at identification and validat...

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• REVIEW  |  02 Jul 2019

  Micropapillary Carcinoma of the Bladder: Recent Advances

  JIM HSU, JAE Y. RO. The 2016 WHO classification of tumors of the urothelial tract recently revised the classification of invasive urothelial carcinoma to include nested, microcystic, micropapillary, plasmacytoid, sarcomatoid, giant cell, and poorly differentiated variants, among others. In particular, invasive micropapillary carcinoma (IMPC) is now recognized as a distinct entity with aggressive f...

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