Annals of Urologic Oncology

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  • Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

    Amit V Varma, Seema Jindal ... Pooja Kesharwani

    Prostate cancer (PCa) is the second most frequent malignancy (after lung cancer) in men worldwide. In prostate cancer, immunohistochemistry (IHC) has an important role in the diagnostic confirmation. Gleason score, tumour volume, surgical margins and Ki-67 index are the most significant prognostic factors. The value of different biomarkers like p53, Ki-67, PSMA, androgen receptor mutations, IGF, E...

    RESEARCH | Published: 30 Aug 2022

    Annals of Urologic Oncology, Volume 5 (2022), Issue 1

    Pages: 20-33   PDF(2310KB)   Views:871Downloads:2

  • Long Term Results of Elective Nodal Salvage Radiotherapy in Oligometastatic Prostate Cancer: A Mono-institutional Series

    Riccardo Vigna-Taglianti, Alberto Boriano ... Elvio Grazioso Russi

    The development of new metabolic diagnostic imaging PET is changing the history of metastatic prostate cancer (pCa), identifying situations of progression with a low disease burden; radiation treatment of metabolically active oligometastatic sites has been shown to be effective to prolong patient survival. In the scenario of oligometastatic disease to pelvic lymph nodes there is no uniform consens...

    RESEARCH | Published: 06 Oct 2022

    Annals of Urologic Oncology, Volume 5 (2022), Issue 1

    Pages: 34-41   PDF(860KB)   Views:755Downloads:1

  • Long Non-coding RNA FAM66C Promotes Prostate Cancer Metastasis via JNK-Mediated Proteasome and Lysosomal Pathway

    Zhenqian Qin, Kongdong Li ... Xuefeng Yuan

    A lower expression of lncRNA FAM66C was noted in the most prostate cancer patients. Knockdown of FAM66C in human prostate cancer DU145 and PC-3 cells promoted EMT and cell migration, which was suppressed by proteasomal inhibitor MG132 and lysosomal inhibitor CQ. Knockdown of FAM66C induced JNK signaling, cell migration and invasion, and activation of proteasome and lysosome pathways were suppresse...

    RESEARCH | Published: 29 Nov 2022

    Annals of Urologic Oncology, Volume 5 (2022), Issue 1

    Pages: 42-51   PDF(2010KB)   Views:601Downloads:1

  • Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt

    Sriram Krishnamoorthy, Hariharasudhan Sekar ... J. Sathish Kumar

    Pseudoepitheliomatous hyperplasia (PEH) is a benign condition marked by reactive epithelial proliferation seen in response to various insults like trauma, infection, persistent inflammation and neoplasia. In this report, we discuss a case of a 35-year-old man who presented with a perineal swelling, later turned into a non-healing ulcer, first diagnosed as PEH. Still, after clinical suspicion, a de...

    CASE REPORT | Published: 25 Dec 2022

    Annals of Urologic Oncology, Volume 5 (2022), Issue 1

    Pages: 52-56   PDF(1240KB)   Views:623Downloads:1

  • A case of malignant pheochromocytoma of the adrenal gland in a young female

    Veda Murthy Reddy Pogula, Ershad Hussain Galeti ... Ayesha Galeti

    Pheochromocytoma is a tumour of the adrenal medulla, derived from catecholamine producing chromaffin cells. Malignant pheochromocytomas constitute 10–25% of all cases. These are difficult to diagnose microscopically. Therefore, malignant pheochromocytomas are diagnosed by the presence of local invasion or metastatic disease. Case presentation We present a case of malignant Pheochromocytoma in a 20...

    CASE REPORT | Published: 30 Dec 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 2

    Pages: 48-55   PDF(1060KB)   Views:1076Downloads:1

  • A rare case of post radiation urinary bladder necrosis in a patient with carcinoma cervix

    Karthikesh Omkaram, Mallikarjuna Reddy Nalabolu ... Ayesha Galeti

    In contrast to proctitis, vaginitis and acute radiation cystitis, late urological complications after pelvic irradiation are rarer, more serious and irreversible. The main disadvantage of radiotherapy is the fact that it affects both cancer and healthy cells located in the tumour area. As a consequence, different complications develop. A large proportion of cancers treated with radiotherapy are lo...

    CASE REPORT | Published: 31 Dec 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 2

    Pages: 56-61   PDF(2396KB)   Views:1150Downloads:2

  • Giant adrenal myelolipoma treated by laparoscopic excision: A case report and review of literature

    Veda Murthy Reddy Pogula, Ershad Hussain Galeti ... Ayesha Galeti

    Adrenal myelolipoma is inevitably a benign neoplasm of the adrenal gland. It is the second most common primary adrenal incidentaloma after adrenocortical adenomas. Adrenal myelolipoma is a rare, benign and non-functional neoplasm, composed of mature adipose and hematopoietic tissue which closely resembles bone marrow. Most of these lesions are small, unilateral and asymptomatic, discovered inciden...

    CASE REPORT | Published: 31 Dec 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 2

    Pages: 62-68   PDF(1550KB)   Views:1054Downloads:1

  • Non-muscle invasive micropapillary urothelial carcinoma of the bladder: Variable use of initial cystectomy versus intravesical bacillus calmette-guérin

    Karishma Gupta, Danly Omil-Lima ... Kyle Scarberry

    Micropapillary urothelial carcinoma (MPUC) is a rare and aggressive histologic variant of bladder cancer. Treatment guidelines recommend forgoing Bacillus Calmette-Guérin (BCG) therapy in favor of early radical cystectomy for non-muscle invasive (NMI)-MPUC due to high rates of disease progression. We aimed to evaluate its management in patients with immediate cystectomy and BCG across various cen...

    RESEARCH | Published: 31 Dec 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 2

    Pages: 69-79   PDF(457KB)   Views:947Downloads:2

  • Oncolytic and immunotherapeutic CG0070 adenovirus for high-risk bacillus calmette-guerin unresponsive bladder cancer

    Evan Austin, Debra Mobley ... Donald Lamm

    To evaluate the response of patients with high-risk bacillus Calmette-Guerin (BCG)–unresponsive non-muscle invasive bladder cancer (NMIBC) who we treated with intravesical CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor (GM-CSF) containing an RB promoter. Methods 15 patients with residual high grade BCG-unresponsive CIS +/- Ta/T1/T2 bladder cancer received one...

    RESEARCH | Published: 31 Dec 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 2

    Pages: 80-86   PDF(633KB)   Views:651Downloads:2

  • Isolated tuberculous epididymal mass mimicking testicular malignancy: An interesting case report and lessons learnt

    Tejaswini Manne, Solomon Nazareth ... Natarajan Kumaresan

    Tuberculous epididymal mass is a condition that presents as a painless scrotal swelling. It resembles a testicular mass and is more often diagnosed after orchidectomy. About 22% of all genitourinary tuberculosis show epididymal involvement and 22% of epididymal tuberculosis are bilateral. This report reiterates the need for an increased awareness amongst the treating urologists that would enable a...

    CASE REPORT | Published: 22 May 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 1

    Pages: 1-4   PDF(1090KB)   Views:1874Downloads:2

  • Isolated large renal hydatid cyst treated by laparoscopic nephrectomy

    Veda Murthy Reddy Pogula, Ershad Hussain Galeti ... Ayesha Galeti

    Hydatid disease is caused by Echinococcus granulosus, which causes rare isolated presentation in the kidneys, and is estimated to be about 2-4% of all cases. We herein present a case of a 45-year-old symptomatic male patient with a large primary hydatid cyst in the left kidney that was treated successfully by laparoscopic left nephrectomy....

    CASE REPORT | Published: 20 Aug 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 1

    Pages: 5-9   PDF(1020KB)   Views:884Downloads:1

  • Squamous cell carcinoma of the urinary bladder: Clinicopathological and molecular update -Review

    Sunil Vitthalrao Jagtap, Swati S Jagtap ... Snigdha Vartak

    Urinary bladder cancer is one of the most prevalent cancers worldwide.Squamous Cell Carcinoma (SCC) is an uncommon subtype of urinary bladder carcinoma.It is a malignant epithelial neoplasm arising in the urinary bladder demonstrating a pure squamous cell phenotype. On histopathology it is considered when tumor is showing pure squamous morphology without any component of conventional urothelial ca...

    REVIEW | Published: 15 Jul 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 1

    Pages: 10-17   PDF(2060KB)   Views:6126Downloads:2

  • Hereditary renal cell tumors: Clinicopathologic importance

    Harmanjot Singh, Mukul K. Divatia ... Jae Y. Ro

    Hereditary renal cancer syndromes represent approximately 5% of renal malignancies and have distinctive clinical, histopathologic, and genetic features. Next-generation sequencing and other molecular testing methods have uncovered several hereditary renal cancer syndromes. Several autosomal dominant hereditary renal cell carcinoma (RCC) syndromes, including those related to germline pathogenic var...

    REVIEW | Published: 15 Oct 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 1

    Pages: 18-30   PDF(4520KB)   Views:1133Downloads:1

  • Roles of renin-angiotensin system in the regulation of prostate cancer bone metastasis: A critical review

    Manh Tien Tran

    Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from (1) the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption and from (2) the anti-tumor immune respon...

    REVIEW | Published: 15 Oct 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 1

    Pages: 31-41   PDF(723KB)   Views:1541Downloads:1

  • Correlation between serum PSA, gleason score and histopathological grading of adenocarcinoma of prostate in patients undergoing TRUS guided prostatic biopsy ...

    Veda Murthy Reddy Pogula, Karthikesh Omkaram ... Bhargava Reddy Kanchi V

    Prostate cancer is the second most common cancer and the fifth leading cause of cancer deaths worldwide. Serum psa, a glycoprotein and a serine protease, which is increased in all prostatic diseases but markedly elevated levels are indicative of carcinoma prostate. The present study was done to evaluate the histopathologyof carcinoma of prostate in trus guided prostatic biopsy specimens and correl...

    RESEARCH | Published: 20 Dec 2021

    Annals of Urologic Oncology, Volume 4 (2021), Issue 1

    Pages: 42-47   PDF(909KB)   Views:1123Downloads:2

  • Open radical retropubic prostatectomy as a saviour in the era of robotics- a single surgeon experience

    Abdul Rouf Khawaja, Malik Abdul Rouf ... Mohd.Saleem Wani

    Outcome of its safety, perioperative outcomes, functional outcomes, oncologic outcomes in open radical retropubic prostatectomy for organ confined prostate cancers in the era of robotic surgery. A prospective study of radical retropubic prostatectomy performed at SKIMS between 2013 and 2020 was conducted. Work up of the patients in the study (n=42) included age, comorbidities, serum prosta...

    RESEARCH | Published: 10 Oct 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 2

    Pages: 54-60   PDF(2060KB)   Views:4078Downloads:1

  • Short term outcomes in Indian patients with high risk prostate cancer after laparoscopic radical prostatectomy- data from a single institute

    Prashant Patel, Shrenik J Shah, Arpan Choudhary

    Management of high risk prostate cancer (HRPC) is in evolving stage. Effectiveness of the various treatment strategies is being explored. We examined the short term efficacy of laparoscopic radical prostatectomy (LRP) in treatment of patients with HRPC. Retrospective observational study had 140 HRPC patients of Indian origin, based on D’Amico classification system. Baseline workup was completed. ...

    RESEARCH | Published: 04 Oct 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 2

    Pages: 61-70   PDF(837KB)   Views:1703Downloads:2

  • Long non-coding RNAs in castration-resistant and neuroendocrine prostate cancer: Potential role and therapeutic impact

    Kumari S. Prajapati, Atul K. Singh ... Sanjay Gupta

    Prostate cancer is the most commonly diagnosed malignancy and leading cause of cancer-related deaths in men worldwide. The disease is heterogeneous in nature exhibiting various clinical subtypes and genetic/transcriptomic features. Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that does not encode any protein and play important role in several biological processes as ...

    REVIEW | Published: 31 Dec 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 2

    Pages: 71-81   PDF(1270KB)   Views:1896Downloads:1

  • Comparative study of histological changes (thermal artefacts) in resected specimens of monopolar and bipolar trans-urethral resection of bladder tumours

    Vasudevan Thirugnanasambandam, Jeyaraman Ramanathan

    The primary aim of the study was to study the histological changes (Thermal artefacts) noted in the resected specimens between the Monopolar and Bipolar Trans-Urethral Resection of Bladder Tumours (TURBT). The study was done between March 2012 and Feb 2013. This was a comparative study between Monopolar and Bipolar resection specimens studied for histological changes (Thermal artefacts). Institu...

    RESEARCH | Published: 04 Nov 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 2

    Pages: 82-88   PDF(939KB)   Views:1738Downloads:2

  • Minimal invasive treatments for renal cell carcinoma

    Selahattin Çalışkan, Mustafa Sungur

    Renal cell carcinoma (RCC) is the most common malignancy of the kidney that accounts 85% of all renal tumors and 2-3% of all adult malignancies . The etiology of RCC associated with smoking , obesity, anti-hypertensive therapy, coffee and tea, Western diet (high fat and protein and low fruits and vegetables). However, the detection of small renal masses has been increased because of widespread us...

    REVIEW | Published: 05 Oct 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 2

    Pages: 89-96   PDF(1080KB)   Views:1337Downloads:2