Table of Contents

• Oncolytic and immunotherapeutic CG0070 adenovirus for high-risk bacillus calmette-guerin unresponsive bladder cancer

  Evan Austin, Debra Mobley ... Donald Lamm

  To evaluate the response of patients with high-risk bacillus Calmette-Guerin (BCG)–unresponsive non-muscle invasive bladder cancer (NMIBC) who we treated with intravesical CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor (GM-CSF) containing an RB promoter. Methods 15 patients with residual high grade BCG-unresponsive CIS +/- Ta/T1/T2 bladder cancer received one...

  RESEARCH | Published: 31 Dec 2021

  Annals of Urologic Oncology, Volume 4, Issue 2

  Pages: 80-86   PDF(633KB)

• Isolated tuberculous epididymal mass mimicking testicular malignancy: An interesting case report and lessons learnt

  Tejaswini Manne, Solomon Nazareth ... Natarajan Kumaresan

  Tuberculous epididymal mass is a condition that presents as a painless scrotal swelling. It resembles a testicular mass and is more often diagnosed after orchidectomy. About 22% of all genitourinary tuberculosis show epididymal involvement and 22% of epididymal tuberculosis are bilateral. This report reiterates the need for an increased awareness amongst the treating urologists that would enable a...

  CASE REPORT | Published: 22 May 2021

  Annals of Urologic Oncology, Volume 4, Issue 1

  Pages: 1-4   PDF(1090KB)

• Isolated large renal hydatid cyst treated by laparoscopic nephrectomy

  Veda Murthy Reddy Pogula, Ershad Hussain Galeti ... Ayesha Galeti

  Hydatid disease is caused by Echinococcus granulosus, which causes rare isolated presentation in the kidneys, and is estimated to be about 2-4% of all cases. We herein present a case of a 45-year-old symptomatic male patient with a large primary hydatid cyst in the left kidney that was treated successfully by laparoscopic left nephrectomy....

  CASE REPORT | Published: 20 Aug 2021

  Annals of Urologic Oncology, Volume 4, Issue 1

  Pages: 5-9   PDF(1020KB)

• Squamous Cell Carcinoma of the Urinary Bladder: Clinicopathological and Molecular Update

  Sunil Vitthalrao Jagtap, Swati S Jagtap ... Snigdha Vartak

  Urinary bladder cancer is one of the most prevalent cancers worldwide.Squamous Cell Carcinoma (SCC) is an uncommon subtype of urinary bladder carcinoma.It is a malignant epithelial neoplasm arising in the urinary bladder demonstrating a pure squamous cell phenotype. On histopathology it is considered when tumor is showing pure squamous morphology without any component of conventional urothelial ca...

  REVIEW | Published: 15 Jul 2021

  Annals of Urologic Oncology, Volume 4, Issue 1

  Pages: 10-17   PDF(2060KB)

• Hereditary renal cell tumors: Clinicopathologic importance

  Harmanjot Singh, Mukul K. Divatia ... Jae Y. Ro

  Hereditary renal cancer syndromes represent approximately 5% of renal malignancies and have distinctive clinical, histopathologic, and genetic features. Next-generation sequencing and other molecular testing methods have uncovered several hereditary renal cancer syndromes. Several autosomal dominant hereditary renal cell carcinoma (RCC) syndromes, including those related to germline pathogenic var...

  REVIEW | Published: 15 Oct 2021

  Annals of Urologic Oncology, Volume 4, Issue 1

  Pages: 18-30   PDF(4520KB)

• Roles of renin-angiotensin system in the regulation of prostate cancer bone metastasis: A critical review

  Manh Tien Tran

  Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from (1) the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption and from (2) the anti-tumor immune respon...

  REVIEW | Published: 15 Oct 2021

  Annals of Urologic Oncology, Volume 4, Issue 1

  Pages: 31-41   PDF(723KB)

• Correlation between serum PSA, gleason score and histopathological grading of adenocarcinoma of prostate in patients undergoing TRUS guided prostatic biopsy ...

  Veda Murthy Reddy Pogula, Karthikesh Omkaram ... Bhargava Reddy Kanchi V

  Prostate cancer is the second most common cancer and the fifth leading cause of cancer deaths worldwide. Serum psa, a glycoprotein and a serine protease, which is increased in all prostatic diseases but markedly elevated levels are indicative of carcinoma prostate. The present study was done to evaluate the histopathologyof carcinoma of prostate in trus guided prostatic biopsy specimens and correl...

  RESEARCH | Published: 20 Dec 2021

  Annals of Urologic Oncology, Volume 4, Issue 1

  Pages: 42-47   PDF(909KB)

• Open radical retropubic prostatectomy as a saviour in the era of robotics- a single surgeon experience

  Abdul Rouf Khawaja, Malik Abdul Rouf ... Mohd.Saleem Wani

  Outcome of its safety, perioperative outcomes, functional outcomes, oncologic outcomes in open radical retropubic prostatectomy for organ confined prostate cancers in the era of robotic surgery. A prospective study of radical retropubic prostatectomy performed at SKIMS between 2013 and 2020 was conducted. Work up of the patients in the study (n=42) included age, comorbidities, serum prosta...

  RESEARCH | Published: 10 Oct 2020

  Annals of Urologic Oncology, Volume 3, Issue 2

  Pages: 54-60   PDF(2060KB)

• Short term outcomes in Indian patients with high risk prostate cancer after laparoscopic radical prostatectomy- data from a single institute

  Prashant Patel, Shrenik J Shah, Arpan Choudhary

  Management of high risk prostate cancer (HRPC) is in evolving stage. Effectiveness of the various treatment strategies is being explored. We examined the short term efficacy of laparoscopic radical prostatectomy (LRP) in treatment of patients with HRPC. Retrospective observational study had 140 HRPC patients of Indian origin, based on D’Amico classification system. Baseline workup was completed. ...

  RESEARCH | Published: 04 Oct 2020

  Annals of Urologic Oncology, Volume 3, Issue 2

  Pages: 61-70   PDF(837KB)

• Long non-coding RNAs in castration-resistant and neuroendocrine prostate cancer: Potential role and therapeutic impact

  Kumari S. Prajapati, Atul K. Singh ... Sanjay Gupta

  Prostate cancer is the most commonly diagnosed malignancy and leading cause of cancer-related deaths in men worldwide. The disease is heterogeneous in nature exhibiting various clinical subtypes and genetic/transcriptomic features. Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that does not encode any protein and play important role in several biological processes as ...

  REVIEW | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3, Issue 2

  Pages: 71-81   PDF(1270KB)

• Comparative study of histological changes (thermal artefacts) in resected specimens of monopolar and bipolar trans-urethral resection of bladder tumours

  Vasudevan Thirugnanasambandam, Jeyaraman Ramanathan

  The primary aim of the study was to study the histological changes (Thermal artefacts) noted in the resected specimens between the Monopolar and Bipolar Trans-Urethral Resection of Bladder Tumours (TURBT). The study was done between March 2012 and Feb 2013. This was a comparative study between Monopolar and Bipolar resection specimens studied for histological changes (Thermal artefacts). Institu...

  RESEARCH | Published: 04 Nov 2020

  Annals of Urologic Oncology, Volume 3, Issue 2

  Pages: 82-88   PDF(939KB)

• Minimal invasive treatments for renal cell carcinoma

  Selahattin Çalışkan, Mustafa Sungur

  Renal cell carcinoma (RCC) is the most common malignancy of the kidney that accounts 85% of all renal tumors and 2-3% of all adult malignancies . The etiology of RCC associated with smoking , obesity, anti-hypertensive therapy, coffee and tea, Western diet (high fat and protein and low fruits and vegetables). However, the detection of small renal masses has been increased because of widespread us...

  REVIEW | Published: 05 Oct 2020

  Annals of Urologic Oncology, Volume 3, Issue 2

  Pages: 89-96   PDF(1080KB)

• Multilocular cystic renal neoplasm-low malignant potential (MCRN-LMP)- review

  Sunil Vitthalrao Jagtap

  Multilocular Cystic Renal Neoplasm of Low Malignant Potential (MCRN-LMP), previously known as multilocular cystic renal cell carcinoma as a rare variant of cystic kidney. It is composed of multiple cysts separated by thin septa covered with clear cells with no expansile growth. The termMCRN-LMPshould be used exclusively to identify a cystic kidney lesion with a small clusters of neoplastic clear c...

  REVIEW | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3, Issue 2

  Pages: 97-102   PDF(874KB)

• Vascular neoplasms and related lesions of kidney

  Michelle S. Lin, Jae Y. Ro

  Vascular tumors arising in the kidney are distinctly uncommon occurrences and have not been well-characterized in the literature; most cases have been documented in single reports or small case series. These tumors often exhibit nonspecific clinical and radiologic features and may mimic malignant epithelial tumors such as renal cell carcinoma (RCC) on imaging studies, necessitating nephrectomy wit...

  REVIEW | Published: 25 Jun 2020

  Annals of Urologic Oncology, Volume 3, Issue 1

  Pages: 1-14   PDF(2840KB)

• Histopathological review of renal pelvic tumours of Balkan nephropathy cases from Southern Serbia

  Diana Herman, Goran Stanojević ... Peter Mantle

  Urothelial tumour frequently associates with atrophied kidney pelvis in Balkan endemic nephropathy but histopathology illustration lacks both definition and immune profile for differential diagnosis from renal cell carcinoma. Histology sections of anonymized archived renal tumours and associated kidney of eight local Balkan nephropathy patients were stained by haematoxylin and eosin, and immune pr...

  RESEARCH | Published: 17 Jul 2020

  Annals of Urologic Oncology, Volume 3, Issue 1

  Pages: 15-21   PDF(5240KB)

• Multilocular cystic renal neoplasm of low malignant potential: Mimicker of cystic clear cell carcinoma – urologist’s perspective

  Harish Challa, Hariharasudhan Sekar ... Natarajan Kumaresan

  Multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) is a rare subtype of clear cell renal cell carcinoma (ccRCC) accounting for 2-4% of RCC. It is defined as a neoplasm that is composed entirely of numerous cysts surrounded by fibrous capsule and septa containing clear cells without expansile growth or mural nodules (WHO 2016). The purpose of this manuscript is to highlight tha...

  CASE REPORT | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3, Issue 1

  Pages: 22-26   PDF(1046KB)

• Effects of P-MAPA as immunomodulator on markers for energy metabolism in bladder cancer

  Wagner J. Fávaro, Petra K. Böckelmann ... N. Durán

  This study characterized and compared cellular energetic metabolism features in the treatment of chemically induced non-muscle invasive bladder cancer (NMIBC) in Fischer 344 rats that were submitted to intravesical immunotherapies with P-MAPA (Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride) and Bacillus Calmette-Guérin (BCG). Our results showed that immunotherapy with...

  RESEARCH | Published: 01 Aug 2020

  Annals of Urologic Oncology, Volume 3, Issue 1

  Pages: 27-35   PDF(3250KB)

• Histologic variants of acinar prostate carcinomas: Clinicopathologic importance

  Harmanjot Singh, Ziad M. El-Zaatari, Jae Y. Ro

  Acinar carcinoma comprises more than 90% of prostatic adenocarcinomas and is characterized by a small gland proliferation with an infiltrative growth pattern. The numerous, variably-defined histological variants of prostatic adenocarcinoma can prove to be diagnostic challenges and show prognostic differences when compared to the usual acinar carcinoma, thus emphasizing the importance in accurate r...

  REVIEW | Published: 31 Dec 2020

  Annals of Urologic Oncology, Volume 3, Issue 1

  Pages: 36-46   PDF(4187KB)

• Histopathological variant types diagnosed in prostate surgery

  Semih Aktaş, Hikmet Köseoğlu ... Sevim Baykal Koca

  Rare pathological variants may only be diagnosed after the surgical treatments applied. We aimed to determine the rare variant pathologies and their frequencies diagnosed in prostate surgeries performed in routine patient care. We retrospectively analyzed hospital pathology records for all prostate surgeries performed namely TUR-P, open prostatectomy, and radical prostatectomy between October 2014...

  RESEARCH | Published: 31 Dec 2021

  Annals of Urologic Oncology, Volume 3, Issue 1

  Pages: 47-53   PDF(4790KB)

• Robot-Assisted Radical Cystectomy: State of Art and Future Perspectives

  Riccardo Mastroianni, Giuseppe Simone

  Bladder cancer (BC) remains one of the most common cancer worldwide. Radical cystectomy (RC) and pelvic lymph node dissection (PLND) with urinary diversion (UD) is still considered the gold standard treatment for non-metastatic muscle invasive bladder cancer (MIBC) and for recurrent non-muscle invasive disease. The open approach remains the reference option of treatment for RC, even if robotic sur...

  REVIEW | Published: 26 Dec 2019

  Annals of Urologic Oncology, Volume 2 , Issue 2

  Pages: 50-56   PDF(6080Kb)