Online First

• REVIEW  |  22 Sep 2019

  Mutations in Cancer Driver Genes: An Insight into Prostate Cancer Progression

  SAHDEO PRASAD, SANJAY K SRIVASTAVA. Prostate cancer is one of the most common uro-oncological disease in men and is globally leading cause of cancer related deaths in males. The somatic mutation has a strong link in the occurrence of cancer. Mutation in the oncogenes and tumor suppressor genes that alter key cellular functions can lead to prostate cancer initiation and progression. Whole genome se...

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• REVIEW  |  15 Sep 2019

  Immunotherapy Landscape in Prostate Cancer: Successes, Failures and Promises

  SABEETH-UR-REHMAN BUTT, MUHAMMAD S KHAN, CARMEN MURIAS, MARIA REYES GONZALEZ-EXPOSITO et al. As research focus in oncology has recently shifted to immunomodulation, the era of introduction of immunotherapeutic agents in the management of prostate cancer has just begun. With the success of checkpoint blockade drugs in certain advanced tumours, ongoing efforts are aimed at identification and validat...

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• REVIEW  |  05 Apr 2019

  Noncoding RNAs and Its Implication as Biomarkers in Renal Cell Carcinoma: A Systematic Analysis

  SHIV VERMA, SANJAY GUPTA . Renal cell carcinoma (RCC) is one of the most devastating disease with higher mortality rates. It comprises several subtypes exhibiting distinct histological features and clinical staging. Despite recent advancement in understanding the biology of RCC success in treatment rates remains dismal. This may be partly due to lack of specific biomarkers for earl...

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• REVIEW  |  24 Jan 2019

  Progress in Research on Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) and Bladder Cancer

  WEI-MING FANG, CHUN CHEN. Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) was first discovered in 1987 and confirmed to be a protein that is mainly expressed on the surface of activated lymphocytes. CTLA-4 is expressed on the surface of T cells and binds to B7 expressed on antigen presenting cells(APCs) to potentially play a role in inhibiting lymphocyte proliferation. Inhi...

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