Annals of Urologic Oncology

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  • Multilocular cystic renal neoplasm-low malignant potential (MCRN-LMP)- review

    Sunil Vitthalrao Jagtap

    Multilocular Cystic Renal Neoplasm of Low Malignant Potential (MCRN-LMP), previously known as multilocular cystic renal cell carcinoma as a rare variant of cystic kidney. It is composed of multiple cysts separated by thin septa covered with clear cells with no expansile growth. The termMCRN-LMPshould be used exclusively to identify a cystic kidney lesion with a small clusters of neoplastic clear c...

    REVIEW | Published: 31 Dec 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 2

    Pages: 97-102   PDF(874KB)   Views:9556Downloads:1

  • Vascular neoplasms and related lesions of kidney

    Michelle S. Lin, Jae Y. Ro

    Vascular tumors arising in the kidney are distinctly uncommon occurrences and have not been well-characterized in the literature; most cases have been documented in single reports or small case series. These tumors often exhibit nonspecific clinical and radiologic features and may mimic malignant epithelial tumors such as renal cell carcinoma (RCC) on imaging studies, necessitating nephrectomy wit...

    REVIEW | Published: 25 Jun 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 1

    Pages: 1-14   PDF(2840KB)   Views:3634Downloads:4

  • Histopathological review of renal pelvic tumours of Balkan nephropathy cases from Southern Serbia

    Diana Herman, Goran Stanojević ... Peter Mantle

    Urothelial tumour frequently associates with atrophied kidney pelvis in Balkan endemic nephropathy but histopathology illustration lacks both definition and immune profile for differential diagnosis from renal cell carcinoma. Histology sections of anonymized archived renal tumours and associated kidney of eight local Balkan nephropathy patients were stained by haematoxylin and eosin, and immune pr...

    RESEARCH | Published: 17 Jul 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 1

    Pages: 15-21   PDF(5240KB)   Views:2170Downloads:0

  • Multilocular cystic renal neoplasm of low malignant potential: Mimicker of cystic clear cell carcinoma – urologist’s perspective

    Harish Challa, Hariharasudhan Sekar ... Natarajan Kumaresan

    Multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) is a rare subtype of clear cell renal cell carcinoma (ccRCC) accounting for 2-4% of RCC. It is defined as a neoplasm that is composed entirely of numerous cysts surrounded by fibrous capsule and septa containing clear cells without expansile growth or mural nodules (WHO 2016). The purpose of this manuscript is to highlight tha...

    CASE REPORT | Published: 31 Dec 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 1

    Pages: 22-26   PDF(1046KB)   Views:2386Downloads:0

  • Effects of P-MAPA as immunomodulator on markers for energy metabolism in bladder cancer

    Wagner J. Fávaro, Petra K. Böckelmann ... N. Durán

    This study characterized and compared cellular energetic metabolism features in the treatment of chemically induced non-muscle invasive bladder cancer (NMIBC) in Fischer 344 rats that were submitted to intravesical immunotherapies with P-MAPA (Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride) and Bacillus Calmette-Guérin (BCG). Our results showed that immunotherapy with...

    RESEARCH | Published: 01 Aug 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 1

    Pages: 27-35   PDF(3250KB)   Views:4104Downloads:0

  • Histologic variants of acinar prostate carcinomas: Clinicopathologic importance

    Harmanjot Singh, Ziad M. El-Zaatari, Jae Y. Ro

    Acinar carcinoma comprises more than 90% of prostatic adenocarcinomas and is characterized by a small gland proliferation with an infiltrative growth pattern. The numerous, variably-defined histological variants of prostatic adenocarcinoma can prove to be diagnostic challenges and show prognostic differences when compared to the usual acinar carcinoma, thus emphasizing the importance in accurate r...

    REVIEW | Published: 31 Dec 2020

    Annals of Urologic Oncology, Volume 3 (2020), Issue 1

    Pages: 36-46   PDF(4187KB)   Views:1714Downloads:2

  • Histopathological variant types diagnosed in prostate surgery

    Semih Aktaş, Hikmet Köseoğlu ... Sevim Baykal Koca

    Rare pathological variants may only be diagnosed after the surgical treatments applied. We aimed to determine the rare variant pathologies and their frequencies diagnosed in prostate surgeries performed in routine patient care. We retrospectively analyzed hospital pathology records for all prostate surgeries performed namely TUR-P, open prostatectomy, and radical prostatectomy between October 2014...

    RESEARCH | Published: 31 Dec 2021

    Annals of Urologic Oncology, Volume 3 (2020), Issue 1

    Pages: 47-53   PDF(4790KB)   Views:1355Downloads:0

  • Robot-Assisted Radical Cystectomy: State of Art and Future Perspectives

    Riccardo Mastroianni, Giuseppe Simone

    Bladder cancer (BC) remains one of the most common cancer worldwide. Radical cystectomy (RC) and pelvic lymph node dissection (PLND) with urinary diversion (UD) is still considered the gold standard treatment for non-metastatic muscle invasive bladder cancer (MIBC) and for recurrent non-muscle invasive disease. The open approach remains the reference option of treatment for RC, even if robotic sur...

    REVIEW | Published: 26 Dec 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 2

    Pages: 50-56   PDF(6080Kb)   Views:1967Downloads:1

  • Progress in Research on Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) and Bladder Cancer

    Wei-Ming Fang, Chun Chen

    Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) was first discovered in 1987 and confirmed to be a protein that is mainly expressed on the surface of activated lymphocytes. CTLA-4 is expressed on the surface of T cells and binds to B7 expressed on antigen presenting cells (APCs) to potentially play a role in inhibiting lymphocyte proliferation. Inhibitors of CTLA-4 were developed to promote t...

    REVIEW | Published: 24 Jan 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 2

    Pages: 57-63   PDF(781KB)   Views:3784Downloads:1

  • Measurement of DNA Damage in Bladder Cancer Patients by Alkaline Comet Assay

    Jahidul Islam, Yearul Kabir

    Bladder cancer is the most common cancer of the urinary tract. This is the first attempt to use alkaline comet assay to evaluate DNA damage in Bangladeshi bladder cancer patients. The results of this study may emphasize to use ACA for routine DNA damage detection, which could be used as a prognostic biomarker of bladder cancer....

    RESEARCH | Published: 29 Dec 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 2

    Pages: 64-70   PDF(1020Kb)   Views:2480Downloads:0

  • Immunotherapy Landscape in Prostate Cancer: Successes, Failures and Promises

    Sabeeh-ur-Rehman Butt, Muhammad S Khan ... Anna Patrikidou

    As research focus in oncology has recently shifted to immunomodulation, the era of introduction of immunotherapeutic agents in the management of prostate cancer has just begun. With the success of checkpoint blockade drugs in certain advanced tumours, ongoing efforts are aimed at identification and validation of new actionable immune targets to consolidate and expand the initial success in other t...

    REVIEW | Published: 15 Sep 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 2

    Pages: 71-88   PDF(1680KB)   Views:3784Downloads:1

  • Mutations in Cancer Driver Genes: An Insight into Prostate Cancer Progression

    Sahdeo Prasad, Sanjay K Srivastava

    Prostate cancer is one of the most common uro-oncological disease in men and is globally leading cause of cancer related deaths in males. The somatic mutation has a strong link in the occurrence of cancer. Mutation in the oncogenes and tumor suppressor genes that alter key cellular functions can lead to prostate cancer initiation and progression. Whole genome sequencing has identified numerous gen...

    REVIEW | Published: 22 Sep 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 2

    Pages: 89-95    PDF(568KB)   Views:3332Downloads:1

  • Noncoding RNAs and Its Implication as Biomarkers in Renal Cell Carcinoma: A Systematic Analysis

    Shiv Verma, Sanjay Gupta

    Renal cell carcinoma (RCC) is one of the most devastating disease with higher mortality rates. It comprises several subtypes exhibiting distinct histological features and clinical staging. Despite recent advancement in understanding the biology of RCC success in treatment rates remains dismal. This may be partly due to lack of specific biomarkers for early detection/prognosis and poor clinical out...

    REVIEW | Published: 05 Apr 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 2

    Pages: 96-106   PDF(1210KB)   Views:3170Downloads:2

  • The Role of Chronic Inflammation in Prostate Carcinogenesis: A Follow-Up Study

    Wei Chen, Liwei Jia ... Gregory T. MacLennan

    To investigate the role of chronic inflammation in prostatic carcinogenesis with an emphasis on cancers of grade group 2 or above. Our findings provide additional data supporting a role for chronic inflammation in the development of prostatic adenocarcinoma....

    RESEARCH | Published: 23 Jan 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 1

    Pages: 1-8    PDF(4840KB)   Views:3097Downloads:1

  • Intraductal Carcinoma of Prostate (IDC-P), Grade Group, and Molecular Pathology: Recent Advances and Practical Implication

    Ashwyna Sunassee, Ghadah Al Sannaa, Jae Y. Ro

    The Gleason grading system for prostatic carcinoma is widely used internationally and is based on microscopic architectural patterns of tumors. Over the years, there have been modifications to the original grading system established by Donald F Gleason in 1966 and refined in 1974 which have subsequently been established by the World ...

    REVIEW | Published: 15 Mar 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 1

    Pages: 9-18    PDF(3360KB)   Views:5059Downloads:1

  • Trends in Primary Kidney Cancer: A South Australian Registry Review

    Richard Hoffmann, Arman Kahokehr ... Darren Foreman

    During 1977-2013 there were 5529 cases of PKC diagnosed. Mean overall survival was 70.6 months (standard deviation 80.2). The age adjusted incidence of PKC has increased from 5 per 100,000 to 12.7 per 100,000. However, CSS and OS has significantly improved at each decade of diagnosis since 1977 (p<0.001)....

    RESEARCH | Published: 05 Nov 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 1

    Pages: 19-25   PDF(990KB)   Views:2789Downloads:1

  • Micropapillary Carcinoma of the Bladder: Recent Advances

    Jim Hsu, Jae Y. Ro

    The 2016 WHO classification of tumors of the urothelial tract recently revised the classification of invasive urothelial carcinoma to include nested, microcystic, micropapillary, plasmacytoid, sarcomatoid, giant cell, and poorly differentiated variants, among others. In particular, invasive micropapillary carcinoma (IMPC) is now recognized as a distinct entity with aggressive f...

    REVIEW | Published: 02 Jul 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 1

    Pages: 26-35   PDF(4610KB)   Views:6283Downloads:0

  • Ovarian-type Tumors (Mullerian Tumors) of the Testis: Clinicopathologic Findings with Recent Advances

    Michelle S Lin, Alberto G Ayala, Jae Y Ro

    Ovarian-type epithelial tumors rarely occur in the human testis and paratesticular region. Histologically, these tumors closely resemble their ovarian counterparts and are therefore classified similarly to ovarian epithelial tumors. Most reported ovarian-type tumor cases are serous tumors, but the full spectrum of ovarian neoplasms has be...

    REVIEW | Published: 16 Mar 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 1

    Pages: 36-45   PDF(1718KB)   Views:3488Downloads:1

  • IgG4 Related Disease of Epididymis, Mimicking Testicular Malignancy – A Rare Entity

    Leela Krishna, Sriram Krishnamoorthy ... Natarajan Kumaresan

    Immunoglobulin G4 related disease (IgG4-RD) is a systemic fibro inflammatory condition that usually presents with multiorgan involvement. We present a rare case of 54 year old male with an isolated IgG4-RD of epididymis. The patient presented with a progressive swelling of the left testicle. ...

    CASE REPORT | Published: 08 May 2019

    Annals of Urologic Oncology, Volume 2 (2019), Issue 1

    Pages: 46-49   PDF(1470KB)   Views:3676Downloads:1

  • Renal Cell Carcinoma

    Peng Zhang, Jae Y. Ro

    Renal cell carcinoma (RCC) refers to a tumor group with heterogeneity derived from renal tubular cells, which form almost all kidney cancer types....

    REVIEW | Published: 15 Nov 2018

    Annals of Urologic Oncology, Volume 1 (2018), Issue 1

    Pages: 1-18    PDF(3538KB)   Views:10216Downloads:3